Scientific Evidences


Performance Recovery

Clinical Study conducted by the Department of Exercise Physiology, UCAM (Catholic University of Murcia): 225 mg Punicalagins/day. Treatment duration: 15 days.                                                  Conclusions: Pomanox supplementation (14 days) on trained cyclists increased total time to exhaustion (TTE) and time to reach ventilatory threshold 2 (VT2) significantly in a maximal test (IETE), after a long endurance effort, compared to placebo. Pomanox, after a prolonged submaximal effort, may be effective for improving performance outcomes in a maximal effort, and might help to restore force in the damaged muscles (4).


Reduction of Stress Levels

Clinical Study: Double-blind, randomised, placebo-controlled exploratory study. All 29 participants consumed either one Pomegranate Extract (Pomanox) or a placebo capsule daily, after a meal, for 4 weeks. Each capsule of Pomanox contained 210 mg Punicalagins.
Conclusions: PE ameliorate cardiovascular risk factors, reduce stress levels and improve -perceived health related quality of life. The reduction in salivary cortisol levels may prove beneficial for people suffering from chronic stress (3).


Improves Mood and Wellbeing

Clinical Study: Placebo-controlled, repeated measure intervention trial in 55 healthy subjects administered Pomanox-enriched pomegranate fruit juice (500mL/day) for 2 weeks. 
Conclusions: Pomanox-enriched Pomegranate juice intake enhances salivary Testosterone levels and improves mood and wellbeing in healthy men and women (9)


Cognitive Performance

Clinical Study, Queen Margaret University (UK): double-blinded, randomised, placebo-controlled crossover pilot (20 participants, 2 week intervention).
Conclusions: Acute consumption of Pomanox (2 capsules containing 210mg Punicalagin) can improve aspects of cognitive performance in healthy adults. 
Compared to placebo, Pomanox significantly increased the accuracy of responses in the picture recognition test and other cognitive tasks. Prepared for publication (10)


Digestive Health

Pilot Human Intervention Study: 115mg Punicalagins/day, 28 days duration. 
Prepared for publication.
Conclusions: The consumption of Pomanox increases levels of beneficial flora(Lactobacillus and Bifidobacterium) and, at the same time, decreases levels of harmful bacteria and improves bowel functions. Proprietary in-vitro and animal studies with Pomanox confirm these properties


Improves Hair Health

Longitudinal, Randomised Clinical Pilot Study: 110mg Punicalagins/day, 60 days duration 20 men with a mean age of 49 years and having no scarring alopecia: Punicalagins 110mg / day. Prepared for publication.
Conclusions: Intake of Pomanox may be of value in hair care, as suggested by: improved test score in the pull test, increased hair density and thickness and increased ratio of hair in the anagen / telogen phase


Healthy Aging

Randomised Study: Punicalagins 80 mg / day for 30 days, 20 participants.
Prepared for publication.
Conclusions: The consumption of Pomanox decreases serum levels of pro-inflammatory cytokines IL1β, IL6, IL8 and TNF-α, and increases serum level of the anti-inflammatory cytokine IL10

1. Vilahur G, et al. Rev Esp Cardiol (Engl Ed). (2015);68(3):216-25 2. Quirós-Fernández R, et al. Nutrients 2019, 11, 640 3. Stockton A, et al. EC Nutrition 2.4. (2015):
396-411 4. Torregrosa-García A, et al. Nutrients 2019, 11, 721 5. Martín-Sánchez F, et al. Cell Death Differ. (2016);23(7):1219-31 6. Dujaili AI, et al. EC Nutrition 4.6 (2016): 
982-995 7. Tsang C, et al. J Nutr Sci. (2012), vol. 1, e9, page 1-9 8. Stockton A, et al. J Nutr Sci. (2017); 6: e39 9. Dujaili AI, et al. Endocrine Abstracts. (2012); 28 P313 
10. Stockton et al, 2018, Unpublished observations.